Protein name:
Ubiquitin carboxyl-terminal hydrolase 14 ;
Alternative:
Ubiquitin thiolesterase 14 ;Deubiquitinating enzyme 14 ;Ubiquitin-specific-processing protease 14 ;
Organism:
Bovine (Bos taurus).
General Annotation
Sub Unit:
Homodimer (Potential). Interacts with FANCC, CXCR4 and ERN1 (By similarity). Associates with the 26S proteasome.
Function:
Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs).
Subcellular Location:
Cytoplasm
Cell membrane
Peripheral membrane protein
Protein Attributes:
50:
MPLYSVTVKW | GKEKFEGVEL | NTDEPPMVFK | AQLFALTGVQ | PARQKVMVKG |
100:
GTLKDDDWGN | IKMKNGMTVL | MMGSADALPE | EPSAKTVFVE | DMTEEQLASA |
150:
MELPCGLTNL | GNTCYMNATV | QCIRSVPELK | DALKRYAGAL | RASGEMASAQ |
200:
YITAALRDLF | DSMDKTSSSI | PPIILLQFLH | MAFPQFAEKG | EQGQYLQQDA |
250:
NECWVQMMRV | LQQKLEAIED | DTVKETDSSS | ASAVTPSKKK | SLIDQFFGVE |
300:
FETTMKCTES | EEEEVTKGKE | SQLQLSCFIN | QEVKYLFTGL | KLRLQEEITK |
350:
QSPTLQRNAL | YIKSSKISRL | PAYLTIQMVR | FFYKEKESVN | AKVLKDVKFP |
400:
LMLDVYELCT | PELQEKMVSF | RSKFKDLEDK | KVNQQPKTGD | KDSSPQKEVK |
450:
YEPFSFADDI | GSNNCGYYDL | QAVLTHQGRS | SSSGHYVSWV | KRKQDEWIKF |
494:
DDDKVSIVTP | EDILRLSGGG | DWHIAYVLLY | GPRRVEIMEE | ESEQ
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Bovine
Rabbit
ELISA Kit for Bovine Ubiquitin carboxyl-terminal hydrolase 14
ELISA Kit for Bovine Ubiquitin carboxyl-terminal hydrolase 14
ELISA Kit for Bovine Ubiquitin carboxyl-terminal hydrolase 14
ELISA Kit for Bovine Ubiquitin carboxyl-terminal hydrolase 14
CLIA Kit for Bovine Ubiquitin carboxyl-terminal hydrolase 14
CLIA Kit for Bovine Ubiquitin carboxyl-terminal hydrolase 14
CLIA Kit for Bovine Ubiquitin carboxyl-terminal hydrolase 14
CLIA Kit for Bovine Ubiquitin carboxyl-terminal hydrolase 14
Polyclonal Antibody for Bovine Ubiquitin carboxyl-terminal hydrolase 14
Polyclonal Antibody for Bovine Ubiquitin carboxyl-terminal hydrolase 14
Polyclonal Antibody for Bovine Ubiquitin carboxyl-terminal hydrolase 14
Polyclonal Antibody for Bovine Ubiquitin carboxyl-terminal hydrolase 14
Monoclonal Antibody for Bovine Ubiquitin carboxyl-terminal hydrolase 14
Monoclonal Antibody for Bovine Ubiquitin carboxyl-terminal hydrolase 14
Monoclonal Antibody for Bovine Ubiquitin carboxyl-terminal hydrolase 14
Monoclonal Antibody for Bovine Ubiquitin carboxyl-terminal hydrolase 14
Protein for Bovine Ubiquitin carboxyl-terminal hydrolase 14
Protein for Bovine Ubiquitin carboxyl-terminal hydrolase 14
Protein for Bovine Ubiquitin carboxyl-terminal hydrolase 14
Protein for Bovine Ubiquitin carboxyl-terminal hydrolase 14
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
Hereford .
tissue :
Fetal pons .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ASSOCIATION WITH THE 26S PROTEASOME